Lucitanib Clinical Development Overview

Lucitanib, an investigational, oral, potent inhibitor of the tyrosine kinase activity of vascular endothelial growth factor receptors 1 through 3 (VEGFR 1-3), platelet-derived growth factor receptors alpha and beta (PDGFRα/β) and fibroblast growth factor receptors 1 through 3 (FGFR 1-3). Clovis has global rights (excluding China) for lucitanib.

Recent data for a drug that inhibits these same three pathways - when combined with a PD-1 inhibitor - are extremely encouraging and represent a scientific rationale for the development of lucitanib in combination with a PD-1 inhibitor, and a Clovis-sponsored Phase 1b/2 study of lucitanib in combination with nivolumab in advanced gynecologic cancers and other solid tumors is currently enrolling.  Based on encouraging data of VEGF and PARP inhibitors in combination, a Phase 1b/2 study of lucitanib in combination with rucaparib in advanced ovarian cancer is also enrolling as an arm of the SEASTAR study. Anticipate initial data from these Clovis-sponsored studies at medical meetings in 2020.

Lucitanib Scientific Presentations

Application of Machine Learning and Grid Search Approaches to Minimize Lucitanib Pharmacokinetic Variability Following Different Dosing Regimens

Poster Presentation 2020 AACR Virtual Meeting II

documentImage.GetPropertyValue(

The Combination of a Mouse Ortholog of ALKS 4230, a Selective Agonist of the Intermediate-Affinity IL-2 Receptor, and the Angiogenesis Inhibitor Lucitanib Enhances Antitumor Activity

Poster Presentation 2020 AACR Virtual Meeting II

documentImage.GetPropertyValue(

Combination of the Angiogenesis Inhibitor Lucitanib with Immune Checkpoint Blockade Augments Anti-tumor Activity in Syngeneic Models

Presented at 2019 SITC

documentImage.GetPropertyValue(